Copper-catalyzed synthesis of 1-amino-5-arylindazolo[3,2-b]quinazolin-7(5H)-ones via a ring-opening reaction of 4-halogenated isatin

143The domino reaction of 4-halogenated isatins and 2-amino-N′-arylbenzohydrazides catalyzed by CuI in the presence of Cs2CO3 is described. This procedure provided an efficient method for the synthesis of fused polycyclic 1-amino-5-arylindazolo[3,2-b]quinazolin-7(5H)-ones derivatives in good yields.