Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5214977 | Tetrahedron | 2015 | 6 Pages |
Abstract
An efficient and facile α-hydroxylation of ketones catalyzed by CuBr2 or HBr in DMSO is developed, providing secondary/tertiary α-hydroxy carbonyl compounds in moderate to good yields (up to 87%). A series of control experiments suggested that water and DMSO may work cooperatively in the hydrolysis step.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Hong-Liang Li, Xing-Lan An, Li-Shi Ge, Xiaoyan Luo, Wei-Ping Deng,