Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5215979 | Tetrahedron | 2014 | 7 Pages |
Abstract
Development of an efficient synthesis of fully substituted pyrroles via a sequential propargylation/amination/cycloisomerization was accomplished using AgSbF6 as a catalyst. The one-pot three-component reaction of propargylic alcohols, 1,3-dicarbonyl compounds, and primary amines proceeds at a mild temperature, which prevents the formation of furan by-product. The reaction was also successfully applied to the more basic aliphatic amines with the addition of 1.1Â equiv of acetic acid.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Satheesh Gujarathi, Xingui Liu, Lin Song, Howard Hendrickson, Guangrong Zheng,