Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5217870 | Tetrahedron | 2013 | 5 Pages |
Abstract
An enantiospecific formal total synthesis of the macrolide (+)-aspicilin is accomplished from chiral pool tartaric acid. Key features of the synthesis include desymmetrization of the bis-dimethyl amide of tartaric acid and further elaboration to the title compound using olefin cross-metathesis and Yamaguchi macrolactonization as the pivotal steps.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Vasudeva Rao Gandi,