| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5218394 | Tetrahedron | 2013 | 11 Pages |
Abstract
Ethyl 4-ethoxyazulene-1-carboxylate (1) is highly efficient and novel substrate for electrophilic substitution reactions. These derivatives (2–4) were treated with NH2NH2/PhNHNH2 in ethanol to produce pyridazine, and fulvene derivatives with azulene frameworks (5, 6, 17, 19) via intramolecular cyclization. The substrates 5–8, 11, and 19 were effectively converted into densely functionalized heterocyclic molecules via Vilsmeier–Haack, Friedel–Crafts, and Michael addition reactions.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
