Use of tosylated glycerol carbonate to access N-glycerylated aza-aromatic species

Tosylated glycerol carbonate was used for N-glyceryl functionalization of diverse aza-aromatic systems. Depending on the pKa of the aza-heterocycle and the reaction conditions applied, original N-alkylated or N-acylated aza-heterocyclic derivatives were obtained. Those compounds carry an electrophilic appendage—either carbonate or epoxide—which allows further useful transformations.

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