Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5273362 | Tetrahedron Letters | 2010 | 4 Pages |
Abstract
Synthesis of α- and β-(aminomethyl)vinylphosphonates was achieved from vinyl bromide via a cross-coupling reaction with triethyl phosphite and by cross-metathesis of allyl bromide and vinylphosphonate, respectively. The 1,3-dipolar cycloaddition of these vinylphosphonates with a dipole in the presence of trifluoroacetic acid afforded selectively the β-aminopyrrolidinephosphonates. Syntheses of cis- and trans-γ-aminopyrrolidinephosphonates are also described.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Nicolas Rabasso, Antoine Fadel,