Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5275912 | Tetrahedron Letters | 2007 | 4 Pages |
Abstract
The conjugate reduction of α,β-unsaturated esters such as acrylates, crotonate, and cinnamates followed by Mannich-type coupling toward aldimines was efficiently promoted by rhodium-bis(oxazolinyl)phenyl catalyst and alkoxyhydrosilanes to show high anti-selectivity up to 99.
Graphical abstractThe coupling reaction with α,β-unsaturated esters and aldimines catalyzed by Rh(Phebox) complex was realized to give β-aminoesters in good to excellent yields with high diastereoselectivity up to 99%.Download full-size image
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Hisao Nishiyama, Junji Ishikawa, Takushi Shiomi,