Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5441531 | Journal of Non-Crystalline Solids | 2017 | 7 Pages |
Abstract
Three-dimensional (3D) nanofibrous scaffolds morphologically mimicking natural extracellular matrix show great potential in the application of tissue repair. Herein, we report a novel 3D nanofibrous silica (SiO2) scaffold fabricated via a sacrificial template method. The sacrificed template used was 3D bacterial cellulose and the resultant silica nanofiber has a ultrasmall diameter of 21Â nm. SEM, TEM, and AFM evidence the 3D porous nanofibrous structure and pore structure measurement confirms the existence of macro- and meso-pores in the as-prepared silica scaffold. Cell studies using osteoblast cells demonstrate excellent biocompatibility and high ALP activity. These results suggest that the 3D silica nanofibrous scaffold is a promising candidate for hard tissue engineering.
Related Topics
Physical Sciences and Engineering
Materials Science
Ceramics and Composites
Authors
Honglin Luo, Zhongyuan Zhou, Gen Li, Wei Li, Zhiqing Li, Guangyao Xiong, Yong Zhu, Fanglian Yao, Ruisong Guo, Yizao Wan,