Reconstruction of randomly under-sampled spectra for in vivo13C magnetic resonance spectroscopy

This study proposes and evaluates a novel approach to acquire 13C data with reduced proton decoupling power deposition and reconstruct in vivo13C spectra of carboxylic/amide metabolite signals using randomly under-sampled data. Because proton decoupling is not needed over a significant portion of data acquisition, this novel approach can effectively reduce the required decoupling power and thus SAR. It opens the possibility of performing in vivo13C experiments of human brain at very high magnetic fields.