Effects of arterial input function selection on kinetic parameters in brain dynamic contrast-enhanced MRI

Article ID	Journal	Published Year	Pages	File Type
5491531	Magnetic Resonance Imaging	2017	36 Pages	PDF

Abstract

The AIF source has a significant impact on absolute kinetic parameters in DCE-MRI, which limits the comparability of kinetic parameters derived from different AIF sources. The effect is also tissue-dependent. The SSS appears to be the best choice for AIF source vessel selection in brain tumor DCE-MRI as it exclusively allowed for WHO grades II/III and III/IV glioma distinction (by vp) and showed the least number of implausible ve values.

Keywords

SSS ICA ROI Ktrans ICC DCE-MRI Dynamic contrast-enhanced MRI AIF Kep CNS central nervous system superior sagittal sinus internal carotid artery intraclass correlation coefficient arterial input function region of interest kinetic parameters

Related Topics

Physical Sciences and Engineering Physics and Astronomy Condensed Matter Physics

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Effects of arterial input function selection on kinetic parameters in brain dynamic contrast-enhanced MRI

Authors

Vera C. Keil, Burkhard Mädler, Jürgen Gieseke, Rolf Fimmers, Elke Hattingen, Hans H. Schild, Dariusch R. Hadizadeh,