Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5499328 | Radiation Physics and Chemistry | 2016 | 31 Pages |
Abstract
The focus of our laboratory's investigation is to study the direct-type DNA damage mechanisms resulting from γ-ray and ion-beam radiation-induced free radical processes in DNA which lead to molecular damage important to cellular survival. This work compares the results of low LET (γ-) and high LET (ion-beam) radiation to develop a chemical track structure model for ion-beam radiation damage to DNA. Recent studies on protonation states of cytosine cation radicals in the N1-substituted cytosine derivatives in their ground state and 5-methylcytosine cation radicals in ground as well as in excited state are described. Our results exhibit a radical signature of excitations in 5-methylcytosine cation radical. Moreover, our recent theoretical studies elucidate the role of electron-induced reactions (low energy electrons (LEE), presolvated electrons (epreâ), and aqueous (or, solvated) electrons (eaqâ)). Finally DFT calculations of the ionization potentials of various sugar radicals show the relative reactivity of these species.
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Radiation
Authors
Michael D. Sevilla, David Becker, Anil Kumar, Amitava Adhikary,