Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5501131 | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2017 | 20 Pages |
Abstract
Several hypotheses have been raised about the dual role of histamine in neurological disorders, and evidences have shown its crucial involvement in the modulation of microglia-mediated neuroinflammation. Previously, we reported that the administration of histamine induces a deleterious effect by promoting a pro-inflammatory phenotype on microglia that in turn compromises dopaminergic neuronal survival. Contrary, under lipopolysaccharide challenge, histamine inhibits the injurious effect of microglia-mediated inflammation, protecting dopaminergic neurons, suggesting that the modulation of microglial activity is dependent on the environmental context. Thus, histamine and/or histamine receptor agonists may serve to develop new therapeutic approaches to overcome neurodegenerative disorders.
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Authors
S. Barata-Antunes, A.C. Cristóvão, J. Pires, S.M. Rocha, L. Bernardino,