Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5501594 | Experimental Gerontology | 2016 | 10 Pages |
Abstract
Our results suggest that acute central effects of leptin on anorexia and hypermetabolism change in disparate ways during aging, implying separate mechanisms (e.g. signal transduction pathways) of different leptin actions. The age-related pattern shown by leptin-induced anorexia may contribute to the explanation of middle-aged obesity, and partly to that of aging anorexia. Our findings concerning obese rats are in accord with previous observations on anorexigenic effects of peripherally administered cholecystokinin: diet-induced obesity appeared to accelerate the development of age-related regulatory alterations. Similarly, our present data also raise the possibility that chronic diet-induced obesity promotes responsiveness to centrally applied leptin at least concerning anorexigenic effects.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Ageing
Authors
I. Rostás, J. Tenk, A. Mikó, N. Füredi, S. Soós, M. Solymár, A. Lengyel, M. Székely, B. Gaszner, D. Feller, E. Pétervári, M. Balaskó,