Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5504095 | Acta Histochemica | 2016 | 9 Pages |
Abstract
Umbilical cord mesenchymal stem cells (UCMSCs) retain their intrinsic stem cell potential while at the same time displaying high proliferation rates, powerful differentiation capacity, and low immunogenicity. They can also secrete multiple bioactive molecules that exert specific physiological functions. Thus, UCMSCs represent excellent candidates for cell therapy in regenerative medicine and tissue engineering. Abundant preclinical research on different disease models has shown that UCMSCs can accelerate wound or nerve damage recovery and suppress tumor progression. In fact, UCMSCs are thought to possess a higher therapeutic potential than MSCs derived from other tissues. Increasing evidence suggests that the mechanism underlying UCSMCs efficacy depends mostly on cell secretions, in contrast to the early paradigm of cell replacement and differentiation. In this review, we discuss UCMSCs biological characteristics, their secretome-based therapeutic mechanism, and potential applications.
Keywords
PI3KASCsMMPEGFLPSIGFMCPMIPPSSMSCsbFGFBMSCsSDFPGE2TCFTIEIκBNGFGDNFMDCDCsTLRIL-1RATGFGM-CSFIDONT-3SCFCCLPDGFUCMSCsEGF-RGSKTPOICAMPGFCXCLHGFB7-H1PlGFTNFRIP-10regulated upon activation normal T-cell expressed and secretedIκKGITRIGFBPaFGFTNF related apoptosis inducing ligandNGFRLIFACTHTNFPDPK1prostaglandin fnatural killerBDNFMS/MSNFκBinterleukin-1 receptor antagonistAngiogenesisAngiogeninAktAnginterferonIFNinterleukinsPAIplasminogen activator inhibitorNerve regenerationtransforming growth factorThrombopoietinELISAEnzyme-linked immunosorbent assayimmunoregulationToll-like receptorTIMPMesenchymal stem cellsUmbilical cord mesenchymal stem cellsadipose tissue-derived mesenchymal stem cellsDendritic cellsCytokineConditioned mediumAnti-tumorTandem mass spectrometryStromal cell-derived factorGranulocyte colony stimulating factorepidermal growth factorHepatocyte growth factorleukemia inhibitory factorgranulocyte-macrophage colony-stimulating factorColony-stimulating factorsTranscription factorsVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)platelet-derived growth factornerve growth factorAcidic fibroblast growth factorbasic fibroblast growth factorInsulin-like growth factorStem Cell FactorG-CSFBrain-derived neurotrophic factorglial cell-derived neurotrophic factortumor necrosis factornuclear factor κBPhosphatidylinositol 3-kinaseTRAILSystemic lupus erythematosusSLEchemokine (C-C motif) ligandlipopolysaccharidechemokine (C-X-C motif) ligand Matrix metalloproteaseCSFMetalloproteinasesMHCmajor histocompatibility complexRANTESinhibitor of kappa Bintercellular adhesion moleculelightneurotrophin-3adrenocorticotropic hormonemonocyte chemotactic proteininsulin-like growth factor binding proteinmacrophage inflammatory proteinProstaglandin E2Macrophage-derived chemokineglycogen synthase kinaseTNF receptorEpidermal growth factor receptornerve growth factor receptor
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Authors
Lipeng Bai, Danting Li, Jie Li, Zhengzhong Luo, Shumin Yu, Suizhong Cao, Liuhong Shen, Zhicai Zuo, Xiaoping Ma,