Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5504188 | Acta Histochemica | 2017 | 7 Pages |
Abstract
Cell migration is a vital process for many physiological and pathological events, and Rho GTPases have been confirmed as key factors in its regulation. The most studied negative regulator of Rho GTPases, Rho-specific guanine nucleotide dissociation inhibitor α (RhoGDIα), mediates cell migration through altering the overall expression and spatiotemporal activation of Rho GTPases. The RhoGDIα-Rho GTPases dissociation can be mediated by signal pathways targeting RhoGDIα directly. This review summarizes the research about the regulation of RhoGDIα during cell migration, which can be in a Rho GTPases association independent manner. Non-kinase proteins regulation, phosphorylation, SUMOylation and extracellular environmental factors are classified to discuss their direct signal regulations on RhoGDIα, which provide varied signal pathways for selective activation of Rho GTPases in cell migration.
Keywords
ERMcyclic AMP-dependent protein kinase AExternal environmentIKKβXIAPRho GTPasesPAK1PDGFIKKpKaPTPECMHCCIκB kinase βphosphatidic acidpost-translational modificationFluorescence resonance energy transferFRETRho kinaseplatelet-derived growth factorExtracellular matrixCell migrationX-linked Inhibitor of Apoptosis ProteinProtein tyrosine phosphataseHepatocellular carcinomaEstrogen receptorRock
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Authors
Fei Xie, Shuai Shao, Aziz ur Rehman Aziz, Baohong Zhang, Hanqin Wang, Bo Liu,