| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5504253 | Advances in Biological Regulation | 2017 | 8 Pages |
Abstract
Rab11 and phosphoinositides are signal transducers able to direct the delivery of membrane components to the cell surface. Rab11 is a small GTPase that, by cycling from an active to an inactive state, controls key events of vesicular transport, while phosphoinositides are major determinants of membrane identity, modulating compartmentalized small GTPase function. By sharing common effectors, these two signal transducers synergistically direct vesicular traffic to specific intracellular membranes. This review focuses on the latest advances regarding the mechanisms that ensure the compartmentalized regulation of Rab11 function through its interaction with phosphoinositides.
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Authors
Carlo Cosimo Campa, Emilio Hirsch,