Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5504779 | Biochemical and Biophysical Research Communications | 2017 | 7 Pages |
Abstract
Metabolic reprogramming contributes to dynamic alteration of cell functions and characteristics. In T cells, TCR-mediated signaling evokes metabolic reprogramming and autophagy. AMBRA1 is known to serve in the facilitation of autophagy and quality control of mitochondria, but the role of AMBRA1 in T cell metabolic alteration is unknown. Here, we show that AMBRA1, but not ATG7, plays a role in TCR-mediated control of glycolytic factors and mitochondrial mass, while both AMBRA1 and ATG7 are required for autolysosome formation. Our results suggested that AMBRA1 is a core factor that controls both autophagy and metabolic regulation.
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Authors
Hisako Akatsuka, Shuhei Kuga, Kaori Masuhara, Odontuya Davaadorj, Chisa Okada, Yumi Iida, Yoshinori Okada, Nahoko Fukunishi, Takahiro Suzuki, Kazuyoshi Hosomichi, Masato Ohtsuka, Masafumi Tanaka, Ituro Inoue, Minoru Kimura, Takehito Sato,