| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5504905 | Biochemical and Biophysical Research Communications | 2017 | 7 Pages |
Abstract
MicroRNAs (miRNAs) have a great effect on regulating tumor cell migration, invasion, proliferation and prognosis. However, the mechanism of miR-1236-3p on regulating carcinogenesis is still unknown. In this study, the expression of miR-1236-3p was lower in lung adenocarcinoma tissues than that in adjacent normal tissue. In lung adenocarcinoma A549Â cell line, miR-1236-3p decreased ability of cell invasion and migration, furthermore, we show that KLF8 is targeted by miR-1236-3p, and expression of miR-1236-3p is negatively correlated with KLF8. Additionally, miR-1236-3p suppressed the expression of KLF8 and EMT (epithelial mesenchymal transition)-related genes. Overexpression of KLF8 can promote EMT-related genes at protein level. In conclusion, our results support the fact that miR-1236-3p acts as a tumor inhibitor in lung adenocarcinoma by suppressing the activity of KLF8, and it may play a critical role in the diagnosis and treatment of lung cancer.
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Authors
Tingting Bian, Daishan Jiang, Jian Liu, Xiaopeng Yuan, Jia Feng, Qian Li, Qing Zhang, Xiaoli Li, Yifei Liu, Jianguo Zhang,