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Low-dose G-CSF improves fat graft retention by mobilizing endogenous stem cells and inducing angiogenesis, whereas high-dose G-CSF inhibits adipogenesis with prolonged inflammation and severe fibrosis

Article ID Journal Published Year Pages File Type
5504934 Biochemical and Biophysical Research Communications 2017 6 Pages PDF
Abstract
Low-dose G-CSF treatment successfully improved fat graft survival by mobilizing HSCs and inducing angiogenesis. However, high-dose G-CSF prolonged inflammation and caused severe fibrosis, leading to impaired adipogenesis and poor fat graft survival.
Keywords
Hematopoietic stem cellgranulocyte colony-stimulating factorMacrophageFat grafting
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
Low-dose G-CSF improves fat graft retention by mobilizing endogenous stem cells and inducing angiogenesis, whereas high-dose G-CSF inhibits adipogenesis with prolonged inflammation and severe fibrosis
Authors
Junrong Cai, Bin Li, Kaiyang Liu, Jingwei Feng, Kai Gao, Feng Lu,
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Journal
Biochemical and Biophysical Research Communications
Journal: Biochemical and Biophysical Research Communications
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