| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5505044 | Biochemical and Biophysical Research Communications | 2017 | 7 Pages |
Abstract
Ischemia/reperfusion (I/R) induces additional damage to the restoration of blood flow to ischemic myocardium. This study examined the effects of urolithin A (UA) on myocardial injury of ischemia/reperfusion in vivo and vitro and explored its underlying mechanisms. Mice were subjected to myocardial ischemia followed by reperfusion. Cells were subjected to hypoxia followed by reoxygenation. UA alleviated hypoxia/reoxygenation (H/R) injury in myocardial cells, reduced myocardial infarct size and cell death in mice after ischemia/reperfusion. Meanwhile, UA enhanced antioxidant capacity in cardiomyocytes following hypoxia/reoxygenation. UA reduced myocardial apoptosis following ischemia/reperfusion. The protection of UA was abolished by LY294002, a PI3K/Akt-inhibitor. These results demonstrated that UA alleviates myocardial ischemia/reperfusion injury probably through PI3K/Akt pathway.
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Authors
Lu Tang, Yingli Mo, Yunpeng Li, Yongkang Zhong, Shangfei He, Ya Zhang, Ying Tang, Shanshan Fu, Xianbao Wang, Aihua Chen,