Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5505132 | Biochemical and Biophysical Research Communications | 2017 | 6 Pages |
Abstract
t-PA binds to Lys91 in the MBP NH2-terminal region and Pg binds to Lys122 in the MBP COOH-terminal region. This proximity promotes the activation of Pg by t-PA. The Pm generated may proteolyze MBP, displacing Pm from the surface which then is inhibited by α2-antiplasmin in the vicinity.257
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Authors
Mario Gonzalez-Gronow, Jenny L. Fiedler, Cristian Farias Gomez, Fang Wang, Rupa Ray, Paul D. Ferrell, Salvatore V. Pizzo,