| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5505189 | Biochemical and Biophysical Research Communications | 2017 | 21 Pages |
Abstract
Antigen's peripheral flanking residues (PFR, positions (p) -p2 and p10) must thus establish strong interactions with the HLA-DRβ* - TCR complex. These amino acids (aa) have specific physico-chemical characteristics enabling differentiation between non-protective but antibody-inducer (NPAI), short-lived protection inducer (SLPI) and long-lasting protection inducer (LLPI) peptides when used as an antimalarial vaccine component. Their identification (through 1H-NMR and Aotus monkey immunization) and proper modification contributes to a logical and rational methodology for long-lasting and protective immunological memory.
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Authors
César Reyes, RocÃo Rojas-Luna, Jorge Aza-Conde, Luisa Tabares, Manuel A. Patarroyo, Manuel E. Patarroyo,