| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5505231 | Biochemical and Biophysical Research Communications | 2017 | 26 Pages |
Abstract
LncRNAs were altered in several cancers and played a crucial role in various biological activities and progressions of different diseases, including proliferation, chemical resistance, and metastasis. In the present study, we revealed that prostrate androgen-regulated transcript-1 (PART-1) was highly expressed in colorectal cancer cells and tissues, and knockdown of PART-1 suppressed cell proliferation and metastasis, both in vitro and in vivo. In addition, PART-1 functioned as a ceRNA of DNMT3A, by sponging miR-143. Finally,PART-1 induced tumor progression by regulating DNMT3A.
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Authors
Yongbo Hu, Zhen Ma, Yiming He, Wei Liu, Yu Su, Zongbin Tang,