| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5505325 | Biochemical and Biophysical Research Communications | 2017 | 6 Pages |
Abstract
We studied the effects of graphene coating on improving the biological activity of a titanium alloy (Ti6Al4V) widely used in hip and knee joint replacements. The experiments included immunofluorescence staining for observing cellular adhesion, Cell Counting Kit-8 (CCK-8) for evaluating cellular proliferation and reverse transcription-polymerase chain reaction (RT-PCR) for detecting the differentiation of bone marrow stromal cells on different scaffolds. The results showed that G-Ti6Al4V exhibited a higher mean integrated optical density (IOD) for vinculin and resulted in a higher cell proliferation rate and higher osteoblast-specific gene transcription levels. In summary, graphene could be used as a new nanocoating material for Ti6Al4V scaffolds to enhance their surface bioactivity.
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Authors
Kewen Li, Jinhong Yan, Chunhui Wang, Long Bi, Qi Zhang, Yisheng Han,