Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5505358 | Biochemical and Biophysical Research Communications | 2017 | 18 Pages |
Abstract
Nephronectin (Npnt), an extracellular matrix protein, is considered to play critical roles as an adhesion molecule in the development and functions of various organs and tissues, such as the kidneys and bone. In the present study, we found that Wnt3a strongly enhanced Npnt mRNA expression in osteoblast-like MC3T3-E1 cells, while it also induced an increase in Npnt gene expression in both time- and dose-dependent manners via the Wnt/β-catenin signaling pathway. These results suggest novel mechanisms for Wnt3a-induced osteoblast proliferation and cell survival via Npnt gene expression.
Keywords
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Mikiko Ikehata, Atsushi Yamada, Naoko Morimura, Masakatsu Itose, Tetsuo Suzawa, Tatsuo Shirota, Daichi Chikazu, Ryutaro Kamijo,