| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5505403 | Biochemical and Biophysical Research Communications | 2017 | 6 Pages |
Abstract
RelE and ParE family toxins belong to the RelE/ParE superfamily, despite distinct biological activities; RelE toxins are a protein synthesis inhibitor by cleaving mRNA, while ParE toxins have inhibitory activity toward Gyr. We found that the Vibrio parahaemolyticus toxin, Vp1843, unlike RelE and ParE toxins, exhibited a DNA nicking endonuclease activity. The present result may assign DNA nicking endonuclease activity of Vp1843 as a third biological activity in the RelE/ParE superfamily toxins.170
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Authors
Jing Zhang, Hironori Ito, Madoka Hino, Makoto Kimura,