| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5505474 | Biochemical and Biophysical Research Communications | 2017 | 6 Pages |
Abstract
Crk interaction with phospho-CD3ζ is rapid and transient, peaking 1 min post TCR/CD3 crosslinking. The results suggest the involvement of Crk adaptor proteins in the early stages of T cell activation in which Crk might help recruiting effector proteins to the vicinity of the phospho-CD3ζ and contribute to the fine-tuning of the TCR/CD3-coupled signal transduction pathways.
Keywords
whole cell lysatespTyrCrk-likePTKGRB2ITAMZAP70SH2LCKWCLCrkLCrkmAbGSTSHCC3GWASPKLHHRPTCrMonoclonal antibodyphosphotyrosineTyrosine phosphorylationT cell activationimmunoreceptor tyrosine-based activation motifNckSignal transductionSrc Homology 2Horseradish peroxidaseProtein tyrosine kinaseslymphocyte-specific protein tyrosine kinaseWiskott–Aldrich syndrome proteingrowth factor receptor-bound protein 2keyhole limpet hemocyaninglutathione S-transferaseT cell antigen receptor
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Authors
Guangyu Dong, Rachel Kalifa, Pulak Ranjan Nath, Sigal Gelkop, Noah Isakov,