Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5505487 | Biochemical and Biophysical Research Communications | 2017 | 4 Pages |
Abstract
The data indicates that kynurenine pathway metabolites are increased in subjects with insulin resistance prior to overt manifestation of hyperglycemia. Moreover, successful metformin treatment leads to a normalization of tryptophan metabolism, most likely as a result of decreased contribution from the kynurenine metabolic pathway.
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Authors
Otto Muzik, Paul Burghardt, Zhengping Yi, Ajay Kumar, Berhane Seyoum,