Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5506335 | Biochemical and Biophysical Research Communications | 2017 | 17 Pages |
Abstract
Centrosomal protein of 192Â kDa (CEP192) is a scaffolding protein that recruits the mitotic protein kinases Aurora A and PLK1 to the centrosome. Here we demonstrate that CEP192 also recruits the type one protein phosphatase (PP1) via a highly conserved KHVTF docking motif. The threonine of the KHVTF motif is phosphorylated during mitosis and protein kinase inhibition studies suggest this to be a PLK1-dependent process.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Isha Nasa, Laura Trinkle-Mulcahy, P. Douglas, Sibapriya Chaudhuri, S.P. Lees-Miller, Kyung S. Lee, Greg B. Moorhead,