Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5506450 | Biochemical and Biophysical Research Communications | 2017 | 5 Pages |
Abstract
The transcription factor p63 belongs to the p53-family and is a master regulator of proliferative potential, lineage specification, and differentiation in epithelia during development and tissue homeostasis. In cancer, p63 contribution is isoform-specific, with both oncogenic and tumour suppressive roles attributed, for ÎNp63 and TAp63, respectively. Recently, p53 and TAp73, in line with other tumour suppressor genes, have emerged as important regulators of energy metabolism and metabolic reprogramming in cancer. To date, p63 contributions in controlling energy metabolism have been partially investigated; given the extensive interaction of the p53 family members, these studies have potential implications in tumour cells for metabolic reprogramming. Here, we review the role of p63 isoforms, TAp63 and ÎNp63, in controlling cell metabolism, focusing on their specific metabolic target genes and their physiological/functional context of action.
Keywords
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Authors
Eleonora Candi, Artem Smirnov, Emanuele Panatta, Anna Maria Lena, Flavia Novelli, Mara Mancini, Giuditta Viticchiè, Maria Cristina Piro, Nicola Di Daniele, Margherita Annicchiarico-Petruzzelli, Gerry Melino,