| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5506559 | Biochemical and Biophysical Research Communications | 2016 | 6 Pages |
Abstract
Indomethacin, diclofenac, and meloxicam highly upregulated radiation-induced expression of ICAM-1 and COX-2 in HUVECs, which suggests that use of these NSAIDs may increase the effects of ionizing radiation and affect the risk of MI after radiation exposure to the heart.
Keywords
NF-κBNSAIDSCOXCOX inhibitorIKKαROINSAIDCOX-2VCAM-1ICAM-1HUVECDMSOcyclooxygenaseMyocardial infarctionionizing radiationtumor necrosis factor-αRelative riskDimethyl sulfoxideHuman umbilical vein endothelial cellEndothelial cellsNon-steroidal anti-inflammatory drugTNF-αNuclear factor-kappa Bintercellular adhesion molecule-1Vascular cell adhesion molecule 1Reactive oxygen intermediatesRadiation
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Authors
Yoshihiko Uehara, Yasuhiko Murata, Soichiro Shiga, Yoshio Hosoi,