| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5506607 | Biochemical and Biophysical Research Communications | 2016 | 6 Pages |
Abstract
The modulation of sino-atrial node (SAN) automaticity is an essential mechanism of heart rate generation that is still not completely understood. Recent studies highlighted the importance of protein serotonylation by intracellular 5-HT during varies physiological actions. Nevertheless, the functional role of protein serotonylation in controlling SAN automaticity is largely unexplored. In this study, we screened the cardiomyocytes proteins and found that sarco(endo)plasmic reticulum Ca ATPase type 2a (SERCA2a) can be serotonylated. Simulation studies using mathematical SAN cell model showed that variation of Ca2+ affinity of SERCA2a pump cause either tachycardia or bradycardia.
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Authors
Qingjie Wang, Dong Wang, Gaoliang Yan, Yong Qiao, Ling Sun, Boqian Zhu, Xin Wang, Chengchun Tang,