| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5506665 | Biochemical and Biophysical Research Communications | 2016 | 25 Pages |
Abstract
Ad-lumican injected animals or fibroblasts presented comparable integrin α2β1 expression while greatly reduced phosphorylation of FAK compared to the negative control. Moreover, Ad-lumican administration largely enhanced the binding of lumican to integrin α2β1 and may thus inhibit the signaling propagation of collagen-integrin α2β1. Overall, the restoration of lumican levels contributed to suppressing the HS progression by inhibiting collagen-integrin α2β1-FAK signaling.
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Authors
Yuqian Zhao, Xueyong Li, Xiaoli Xu, Zhi He, Lei Cui, Xiaoxing Lv,