Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5507370 | Biochimica et Biophysica Acta (BBA) - Biomembranes | 2017 | 38 Pages |
Abstract
Fourteen contiguous residues of the 8th transmembrane domain (pink) are accessible to MTSEA-biotin. Accessibility of six of these residues (Blue type:_AA_HLP_L) is blocked by folate substrate. A homology model in the inward- and outward- open conformations suggests that flexibility in the exofacial region during carrier cycling can account for the extended accessibility.75
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Authors
Srinivas Aluri, Rongbao Zhao, Andras Fiser, I. David Goldman,