Interactions and cooperativity between P-glycoprotein structural domains determined by thermal unfolding provides insights into its solution structure and function

Article ID	Journal	Published Year	Pages	File Type
5507573	Biochimica et Biophysica Acta (BBA) - Biomembranes	2017	54 Pages	PDF

Keywords

Cooperative unit PMT IMP CFTR MUT PGP ICL TMD PoPC NBD AMPPCP DDM SEC ΔHc MDR ΔTm DSC DLS 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine 1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine ABC transporter n-dodecyl-β-d-maltopyranoside P-glycoprotein calorimetric enthalpy large unilamellar vesicle Intracellular loop nucleotide binding domain transmembrane domain circular dichroism cystic fibrosis transmembrane conductance regulator Intrinsic fluorescence Photomultiplier tubes LUV Multidrug resistance Detergent wild type POPE Light scattering Dynamic Light Scattering Integral membrane protein Differential scanning calorimetry Size exclusion chromatography

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Interactions and cooperativity between P-glycoprotein structural domains determined by thermal unfolding provides insights into its solution structure and function

Authors

Zhengrong Yang, Qingxian Zhou, Leo Mok, Anukriti Singh, Douglas J. Swartz, Ina L. Urbatsch, Christie G. Brouillette,