| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5507667 | Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms | 2017 | 36 Pages |
Abstract
Our findings suggest that the characterization of the expression levels of the different FMR1 isoforms is fundamental for understanding the regulation of the FMR1 gene as imbalance in their expression could lead to an altered functional diversity with neurotoxic consequences. Their characterization will also help to elucidating the mechanism(s) by which “toxic gain of function” of the FMR1 mRNA may play a role in FXTAS and/or in the other FMR1-associated conditions.
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Authors
Elizabeth Tseng, Hiu-Tung Tang, Reem Rafik AlOlaby, Luke Hickey, Flora Tassone,