| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5507952 | Biochimica et Biophysica Acta (BBA) - General Subjects | 2017 | 39 Pages |
Abstract
Our data identifies extracellular cytochrome c as a potential intercellular signaling molecule, which may be recognized by microglia causing or enhancing their immune activation. The data obtained support targeting TLR4 and JNK signaling as potential treatment strategies for brain diseases characterized by excessive cellular death and activation of microglia.
Keywords
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Ayden Gouveia, Ekta Bajwa, Andis Klegeris,