Article ID Journal Published Year Pages File Type
5508021 Biochimica et Biophysica Acta (BBA) - General Subjects 2017 55 Pages PDF
Abstract
These data explain why oxamate or AOA, through their multisite inhibitory actions on glycolysis or OxPhos, may be able to decrease the proliferation of cancer cells.
Keywords
PDHALAPEPeNOMDHenolaseAATGLUTPFK-12-DeoxyglucoseFFAsDCAPYROAAPDKOxaloacetate2OGHydroxycitrate2PGFru6P2-DOGGlc6PMALGAPDHG3PDHAPOXPHOSASPhpiAOATPI2-oxoglutarate dehydrogenase2-oxoglutarate2-phosphoglycerateALATALDaspartateAspartate aminotransferasealanineAlanine aminotransferaseAldolaseAminooxyacetateerythrose-4-phosphateFree fatty acidsGlucose transporterdihydroxyacetone phosphateDichloroacetateCancerTriose phosphate isomeraseCitrate synthasefructose-6-phosphatefructose-1,6-bisphosphatephosphoenolpyruvateOxidative phosphorylationPhosphofructokinase-1lactate dehydrogenaseLDHmalateKinetic modelingmalate dehydrogenasehexokinasePyruvatepyruvate dehydrogenasePyruvate dehydrogenase kinasePYKglucose-6-phosphateglucose-6-phosphate dehydrogenaseglyceraldehyde-3-phosphate glyceraldehyde-3-phosphate dehydrogenaseGlycolysis
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
Assessment of the low inhibitory specificity of oxamate, aminooxyacetate and dichloroacetate on cancer energy metabolism
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