Biphasic Ccl20 regulation by Toll-like receptor 9 through the activation of ERK-AP-1 and non-canonical NF-ÎºB signaling pathways

Article ID	Journal	Published Year	Pages	File Type
5508029	Biochimica et Biophysica Acta (BBA) - General Subjects	2017	13 Pages	PDF

Abstract

Our study will help to better understand immune regulation by Ccl20 in the intestine and may be exploited for future development of novel therapeutics against IBD.

Keywords

ActD DNA-dependent activator of IFN-regulatory factors MAP-kinases CCL20 ILF FAE LTβR PRR TLR PAMP TLR9 AP-1 IBD PBMC IDC Bacterial DNA MAPKs pathogen-associated molecular pattern follicle-associated epithelium actinomycin D Inflammatory bowel disease Toll-like receptor epithelial cells peripheral blood mononuclear cells Dendritic cells Intestinal epithelial cells Isolated lymphoid follicles lymphotoxin β receptor Peyer's patches IEC PRR, Pattern recognition receptor

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry

Biphasic Ccl20 regulation by Toll-like receptor 9 through the activation of ERK-AP-1 and non-canonical NF-ÎºB signaling pathways

Authors

Pujarini Dutta, Atri Ta, Bhupesh Kumar Thakur, Nirmalya Dasgupta, Santasabuj Das,