Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5508098 | Biochimica et Biophysica Acta (BBA) - General Subjects | 2017 | 21 Pages |
Abstract
We recently demonstrated that a novel storage and transport mechanism for nitric oxide (NO) mediated by glutathione-S-transferase P1 (GSTP1) and multidrug resistance protein 1 (MRP1/ABCC1), protects M1-macrophage (M1-MÃ) models from large quantities of endogenous NO. This system stores and transports NO as dinitrosyl-dithiol-iron complexes (DNICs) composed of iron, NO and glutathione (GSH). Hence, this gas with contrasting anti- and pro-tumor effects, which has been assumed to be freely diffusible, is a tightly-regulated species in M1-MÃs. These control systems prevent NO cytotoxicity and may be responsible for delivering cytotoxic NO as DNICs via MRP1 from M1-MÃs, to tumor cell targets.
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Authors
Z. Kovacevic, S. Sahni, H. Lok, M.J. Davies, D.A. Wink, D.R. Richardson,