| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5508288 | Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | 2017 | 33 Pages |
Abstract
41 genes in gene cluster 1 and 14 genes in cluster 2 were significantly differentially methylated in dependency of NAFLD and hepatic fibrosis. We detect new genes significantly changed in methylation, including APO family members (lipid transport), NPC1L1, STARD (cholesterol transport) and GRHL (energy homeostasis). Our results allow novel insights into the hepatic epigenetic regulation of genes important for lipid and vitamin D balance in NAFLD.
Keywords
NAFLDLipid and lipoprotein metabolismLXRαVLDLVDRT2DMFFAsPGC-1αHDLFGF-2PPARSREBP-225-hydroxyvitamin Dapoapolipoproteinsimple steatosisnonalcoholic steatohepatitisFree fatty acidsNonalcoholic fatty liver diseaseType 2 diabetes mellitusTranscriptionMetabolic syndromebody mass indexBMIendoplasmic reticulumfibroblast growth factor 2high density lipoproteinvery low density lipoproteinlow density lipoproteinLDLMethylationNash Liverliver X receptor αfree cholesterolperoxisome proliferator-activated receptorVitamin D receptor
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Authors
Jessica Mwinyi, Adrian E. Boström, Claudia Pisanu, Susan K. Murphy, Wiebke Erhart, Clemens Schafmayer, Jochen Hampe, Cynthia Moylan, Helgi B. Schiöth,