| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5508511 | Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | 2017 | 31 Pages |
Abstract
We provide the first comprehensive investigation of SREs and NF-Ys in the human HMGCR and SQLE promoters, increasing our fundamental understanding of the transcriptional regulation of cholesterol synthesis.
Keywords
ChIP-SeqSQLERoswell Park Memorial Institute medium 1640nuclear factor-YNF-Y7-dehydrocholesterol reductaseDHCR7DHCR24PBGDSREFCSHMGCRLDLRRPMISREBP-224-dehydrocholesterol reductase3-Hydroxy-3-Methylglutaryl-coenzyme A reductaseSp1Electrophoretic mobility shift assaysqualene epoxidaseChromatin immunoprecipitation-sequencingTranscriptional regulationfetal calf serumEMSA یا electrophoretic mobility shift assay Specificity protein 1porphobilinogen deaminaselow density lipoprotein receptor
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Authors
Vicky Howe, Laura J. Sharpe, Anika V. Prabhu, Andrew J. Brown,