Src-family tyrosine kinases and the Ca2Â + signal

In this review, we shall describe the rich crosstalk between non-receptor Src-family kinases (SFKs) and the Ca2 + transient generated in activated cells by a variety of extracellular and intracellular stimuli, resulting in diverse signaling events. The exchange of information between SFKs and Ca2 + is reciprocal, as it flows in both directions. These kinases are main actors in pathways leading to the generation of the Ca2 + signal, and reciprocally, the Ca2 + signal modulates SFKs activity and functions. We will cover how SFKs participate in the generation of the cytosolic Ca2 + rise upon activation of a series of receptors and the mechanism of clearance of this Ca2 + signal. The role of SFKs modulating Ca2 +-translocating channels participating in these events will be amply discussed. Finally, the role of the Ca2 + sensor protein calmodulin on the activity of c-Src, and potentially on other SFKs, will be outlined as well. This article is part of a Special Issue entitled: ECS Meeting edited by Claus Heizmann, Joachim Krebs and Jacques Haiech.