| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5508697 | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2016 | 28 Pages |
Abstract
Our results suggest the hypothesis that inhibition of the glycolytic pathway, inactivation of peIF2α and a reduction of basal autophagy could be suitable targets for novel combination therapies in a specific subgroup of metastatic melanoma.
Keywords
BRAFGAPDHERKFskMCTCREBpKaDNPRHCforskolinPGC-1αPMSFMITFPDK1CDK4OCRPDHMc1rMCT4MBTHNDP-MSHOXPHOSFBSDMEMPBSHIF-1TCAcAMPDMSOH2DCFDAMAPKDulbecco's modified Eagle's mediumROSAdenosine TriphosphateATPCyclic adenosine monophosphatetyrosine hydroxylaseMelanomadinitrophenolDimethyl sulfoxidefetal bovine serumendoplasmic reticulumhypoxia-inducible factor-1Microphthalmia-associated transcription factorphosphate buffer salineOxidative phosphorylationphenylmethylsulfonyl fluorideLactatelactate dehydrogenaseLDHMetastatic melanomamonocarboxylate transporterOxygen consumption ratescAMP response element binding proteinprotein kinase Amitogen-activated protein kinasepyruvate dehydrogenasePyruvate dehydrogenase kinase 1tricarboxylic acid cycleextracellular signal-regulated kinaseglyceraldehyde 3-phosphate dehydrogenaseReactive oxygen speciesMelanocortin 1 receptor
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Authors
Anna Ferretta, Immacolata Maida, Stefania Guida, Amalia Azzariti, Letizia Porcelli, Stefania Tommasi, Paola Zanna, Tiziana Cocco, Michele Guida, Gabriella Guida,