| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5508744 | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2017 | 47 Pages |
Abstract
Taken together, these findings demonstrate a crucial role for S1P signaling axis in the proliferation and the survival of otic vesicle neuroprogenitors, highlighting the identification of possible novel therapeutical approaches to prevent neuronal degeneration during hearing loss.
Keywords
Sphingosine 1-phosphate receptorS1PRS1PSK2FGF2SGNINF-γSPLSPPDTTSK1FBSDMEMPI3KPBSSPNS2BSADulbecco's modified Eagle MediumIgf1ROSbovine serum albuminSphingosine 1-phosphate lyaseSphingosine kinase 1Sphingosine kinase 2sphingosine 1-phosphateinterferon-γSurvivalProliferationdithiothreitolfetal bovine serumfibroblast growth factor 2Phosphate buffered salinePhosphatidylinositol 3-kinaseknock-outSpiral ganglion neuronsReactive oxygen speciesSphingosine 1-phosphate receptors
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Authors
Marina Bruno, Ilaria Maria Rizzo, Ricardo Romero-Guevara, Caterina Bernacchioni, Francesca Cencetti, Chiara Donati, Paola Bruni,