Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5508861 | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2017 | 34 Pages |
Abstract
The elaborate membrane architecture of mitochondria is a prerequisite for efficient respiration and ATP generation. The cristae membranes, invaginations of the inner mitochondrial membrane, represent a specialized compartment that harbors the complexes of the respiratory chain and the F1Fo-ATP synthase. Crista junctions form narrow openings that connect the cristae membranes to the inner boundary membrane. The mitochondrial contact site and cristae organizing system (MICOS) is located at crista junctions where it stabilizes membrane curvature and forms contact sites between the mitochondrial inner and outer membranes. MICOS is a large machinery, consisting of two dynamic subcomplexes that are anchored in the inner membrane and expose domains to the intermembrane space. The functions of MICOS in mitochondrial membrane architecture and biogenesis are influenced by numerous interaction partners and the phospholipid environment.
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Authors
Heike Rampelt, Ralf M. Zerbes, Martin van der Laan, Nikolaus Pfanner,