Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5508878 | Biochimie | 2017 | 25 Pages |
Abstract
Influenza virus and coronavirus epidemics or pandemics have occurred in succession worldwide throughout the early 21st century. These epidemics or pandemics pose a major threat to human health. Here, we outline a critical role of the host cell protease TMPRSS2 in influenza virus and coronavirus infections and highlight an antiviral therapeutic strategy targeting TMPRSS2.
Keywords
PAI-1HAI-2human airway trypsin-like proteaseType II transmembrane serine proteaseFDAPPMOTMPRSS2TMPRSS4IFITM(2S,3S)-trans-Epoxysuccinyl-l-leucylamido-3-methylbutane ethyl esterHGFPAR-2AEBSFMMP-2RBSCOVESTBromhexine hydrochlorideThéTherapeuticsFood and Drug AdministrationHepatocyte growth factorMatrix metalloproteinase-2plasminogen activator inhibitor 1AREInfluenza virusprotease activated receptor 2CoronavirusHAT
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Li Wen Shen, Hui Juan Mao, Yan Ling Wu, Yoshimasa Tanaka, Wen Zhang,