| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5509449 | Cellular Signalling | 2017 | 7 Pages |
â¢NHR domains are highly conserved domains that regulate protein-protein interactions.â¢NHR domain proteins regulate numerous cellular and developmental processes.â¢Structural similarity between NHR and SPRY domains.
Neuralized Homology Repeats (NHRs) were first identified in Neuralized, an E3-ubiquitin ligase that plays a key role in the Notch signalling pathway. Since their original discovery, NHR domains have been shown to regulate protein-protein interactions in a broad range of developmental processes and in a wide variety of species from flies to humans. The NHR family of proteins can be categorized into three groups: (1) those that contain a RING finger, (2) those that contain a SOCS box and, (3) those that only have NHR domains. Here we review the structure and function of NHR domains in various cellular and developmental processes.
