Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5509624 | Clinica Chimica Acta | 2017 | 28 Pages |
Abstract
The initial clinical manifestation of ischemic heart disease (IHD) i.e. unheralded myocardial infarction (MI) versus chronic angina pectoris (AP) is statistically associated with adverse or mild disease progression respectively in the long-term follow-up. Here, we subjected AP and MI patients to blood proteomic analysis by Surface-Enhanced Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (SELDI-TOF-MS) in order to investigate putative new prognostic biomarkers of IHD manifestation. We found several differentially expressed peaks but four of them (4176, 4475, 14,158Â m/z and 8922Â m/z for AP and MI, respectively) were most reliable. Two of them were identified; 14,158Â m/z peak was the double-charged form of Apolipoprotein A-I and its vasoprotective action accords with prominence in AP. The 4176Â m/z peak was related to FAM83C protein, while neither the 4475Â m/z peak nor the MI-linked 8922Â m/z peak could be identified. We conclude that SELDI-TOF-MS analysis may yield a panel of molecular signals able to retrospectively classify patients according to their clinical and molecular features, exploitable for predicting the natural course of IHD.
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Authors
Francesca Scebba, Massimo Papale, Silvia Rocchiccioli, Nadia Ucciferri, Federico Bigazzi, Tiziana Sampietro, Clara Carpeggiani, Antonio L'Abbate, Flavio Coceani, Debora Angeloni,